date:Oct 22, 2012
ation of resveratrol, quercetin and catechin induced apoptosis in gefitinib-resistant breast cancer cells through regulation of a range of proapoptotic proteins. Gefitinib is a selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain.
The red grape polyphenols were also found to reduce the Akt activity, induce the activation of AMP kinase and inhibit mTOR signaling in the breast cancer cells with or without the presence of gefitinib although the combination of gr