date:Apr 11, 2017
ell. This process preserves the function of cellular organelles. As we age, autophagy declines.
The scientists found that two proteins, called Sirtuin 1 and AMPK, which sense changes in metabolism, were reduced upon infection. AMPK detects the loss of energy in the cell, which activates autophagy. Sirtuins also sense metabolism decline. Both are activated when there is an energy demand.
An infection causes an energy loss that enhances autophagy. But after cells were infected with Salmonella ba