date:Jul 14, 2012
on the basis of a NOAEL of 1mg/kg from 2-years rats, mice and dogs studies as a point of departure.
The new toxicological studies, mechanistic data, epidemiologic and biomonitoring studies submitted to the US EPA and the new information provided in the literature seem to support NOAELS for acute AChE inhibition of 2mg/kg for brain and 0.5mg/kg for red blood cells, and NOAELS for AChE inhibition after repeated exposure of 0.5mg/kg for brain and 0.1mg/kg for red blood cells,wrote the BfR in its