date:Apr 03, 2013
effects of the annatto-tocotrienols on the spontaneous development of mammary tumors in HER-2/neu transgenic mice, an aggressive form of the disease found in 20-30% of metastatic breast cancers.
Animals received 0, 50 or 100 mg/kg of annatto-tocotrienols in olive oil three times per week.
Results showed a dose-dependent inhibition of cell growth and increased cell death (apoptosis) of the cancer cells. An increase in reactive oxygen species was also observed
The researchers also noted a rapi