date:Nov 15, 2012
ll, the hydrophobic cavity inside the ring allows them to accommodate other hydrophobic substances. Lipophilic curcumin, in other words, can slip inside the cyclodextrin ring. The hydrophilic surface of the resulting complex increases bioavailability and, as such, makes curcumin more soluble within the human body.
The effect has been demonstrated experimentally: solubility of the cyclodextrin-curcumin complex was determined in a simulated digestive fluid. Subsequently, CaCo-2 cells (a line of h